MK-677 (Ibutamoren) is an orally active small molecule commonly studied for its actions on the growth hormone (GH) axis through selective interaction with the ghrelin (GHS-R1a) receptor. Unlike direct growth hormone or GHRH analogs, MK-677 is investigated for its ability to influence endogenous GH and insulin-like growth factor-1 (IGF-1) signaling via sustained receptor-mediated pathway activation. In experimental models, MK-677 is evaluated for its relevance in studies examining endocrine signaling dynamics, metabolic regulation, sleep-associated pathways, and age-related hormonal signaling, where prolonged GH-axis engagement is of research interest.
